History

H1 2003 gestation & validation of business concept

H2 2003 incorporation of De Mello Holding S.A. in Luxembourg

H1 2004 establishing of scientific and business advisory board

H2 2004 due dilligence on investment candidates

H1 2005 participations in affiliated companies Embryonics (60%) and Van Leeuwenhoeck Research Institute (33,3%). Bridgeloan to Triton Biosciences

H2 2005) investing in portfolio companies: Pantarhei Bioscience (7%), GeneMore (11%), due dilligence on investment candidates

H1 2006 investing in portfolio company ProteoNic (15%), participation in Pantarhei Devices (3%) as spin-off company of Pantarhei Bioscience

H1 2006 sell back shares Van Leeuwenhoeck Research Institute to management, due dilligence on investment candidates

H2 2006 repayment bridgeloan Triton Biosciences

H2 2006 shareholders and investors day De Mello - Wassenaar - The Netherlands