GeneMore Holding

GeneMore developes and provides a patented technology platform for the precise and rapid quantification of genes and gene products in a relatively simple and extremely repetitive manner, mainly using the real time Polymerase Chain Reaction (PCR) approach.
GeneMore is initiated by Prof. Andrea Cossariza as a spin-off from the University of Modena and Reggio Emilia in Italy. Prof. Cossariza and his team of the department of Biomedical Sciences, are leading in the field of HIV research and mitochondrial toxicity of antiretroviral drugs. The GeneMore platform is successfully used in several studies to analyse mitochondrial functionality and to measure DNA content, as well as to quantify the production of T lymphocytes in the thymus.
The novelty of the method is that instead of performing a PCR for each gene or gene product seperately in order to calculate their ratio, this technique can perform only one PCR for all the products at the same time. This approach allows excluding technical errors which might influence the calculation of the ratio and producing fast, precise and cheaper results.

There is a large variety of possible applications in several fields (human and veterinary medicine, agriculture and food control) like:

calculating the exact number of copies of mitochondrial DNA in a cell, usefull to evaluate the early stage damages caused by antiretroviral drugs (treatment of HIV or HIV infection)

calculating in vitro the influence of new drugs on mitochondrial DNA, and thus cells and organs, and to perform large screenings on new molecules (pharmaceutical and R&D)

calculating of the relative ratio of genes that cause cell death in patients with different pathologies (autoimmunity, leukemia, etc.)

Many other applications are discovered and can be found in the future, as the methodology allows the quantification of any kind of known or sequenced DNA or RNA, in any living or not living organism.